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SXR/PXR

PXR/SXR is also thought to be responsible for switching on genes in response to environmental pollutants that are potential teratogens [173]. Being able to predict this potential activity is of definite value for developmental toxicology of environmental chemicals. [Pg.335]

PXR (SXR) RXR PB, ortho-PCBs, organochlorine pesticides, dexamethasone, pregnenalone, corticosterone, bile acids (lithocholic acid) CYP3A, CYP2B, CYP7A (repression) GST, ABC transporters... [Pg.192]

SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl Acad. Sci. USA 98, 3375-3380. [Pg.182]

S. Safe, B. Blumberg et al. (2000). Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev. 14, 3014-3023. [Pg.340]

Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM (2001) An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98 3375-3380... [Pg.808]

See other pages where SXR/PXR is mentioned: [Pg.470]    [Pg.471]    [Pg.241]    [Pg.316]    [Pg.335]    [Pg.335]    [Pg.337]    [Pg.31]    [Pg.470]    [Pg.471]    [Pg.241]    [Pg.316]    [Pg.335]    [Pg.335]    [Pg.337]    [Pg.31]    [Pg.7]    [Pg.293]    [Pg.300]    [Pg.313]    [Pg.314]    [Pg.335]    [Pg.387]    [Pg.189]    [Pg.544]    [Pg.7]    [Pg.72]    [Pg.79]    [Pg.340]    [Pg.320]    [Pg.329]    [Pg.453]    [Pg.463]    [Pg.79]    [Pg.46]    [Pg.50]    [Pg.56]    [Pg.98]    [Pg.99]    [Pg.140]    [Pg.205]    [Pg.205]    [Pg.241]    [Pg.313]    [Pg.325]    [Pg.325]    [Pg.341]    [Pg.424]    [Pg.122]    [Pg.181]    [Pg.599]   
See also in sourсe #XX -- [ Pg.166 , Pg.223 , Pg.226 , Pg.233 ]



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PXR

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