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PXR knock-out mice

The Evans lab at the Salk Institute first reported the creation of PXR knock-out mice [6], In that case, to create PXR null mice, the mouse PXR genomic DNA was isolated [Pg.186]

Bile acids are the end products of hepatic cholesterol catabolism and play essential roles in eliminating cholesterol from the body. However, pathophysiological accumulation of bile acids elicits cytotoxicity and can lead to cholestasis in livers. PXR plays a critical role in bile acid detoxification, by regulating bile add biosynthesis, transport and metaboUsm. Stndies in PXR knock out and humanized PXR mice revealed that PXR reduces secondary bile acid lithocholic add (LCA)-induced liver toxidty [77], PXR regulates... [Pg.795]

A variety of GEM models are now available in which aspects of mouse metabolism have been replaced by their human counterparts. Mice with knocked-out mouse pregnane X receptor (mPXR) and knocked-in human PXR (hPXR) have been available for some time. Now, mice with knocked-out mouse constitutive androstane receptor (mCAR) and knocked-in human CAR (hCAR) and mice with both hPXR and hCAR have been generated.63... [Pg.277]

See other pages where PXR knock-out mice is mentioned: [Pg.124]    [Pg.124]    [Pg.126]    [Pg.132]    [Pg.173]    [Pg.186]    [Pg.188]    [Pg.190]    [Pg.124]    [Pg.124]    [Pg.126]    [Pg.132]    [Pg.173]    [Pg.186]    [Pg.188]    [Pg.190]    [Pg.52]    [Pg.117]    [Pg.121]    [Pg.125]    [Pg.128]    [Pg.129]    [Pg.188]    [Pg.190]    [Pg.194]    [Pg.200]    [Pg.282]    [Pg.793]    [Pg.74]    [Pg.190]    [Pg.125]   
See also in sourсe #XX -- [ Pg.186 , Pg.187 ]



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