Purity of crude products

Isobutyl chloroformate has become the most widely used reagent for the preparation of mixed anhydrides for peptide synthesis. The method provides rapid reaction rates at low temperatures, high yields of readily purifiable products, easily removable side products, high purity of crude products, and low cost reagents which are commercially available. These characteristics result in a routine and widely used technique, which can be easily scaled up to the industrial level. 

A response can be, e.g. the yield (expressed in percent, grams, tons etc.), purity of crude product, cost of producing a ton of purified product, or reaction time for obtaining a 90 % conversion of starting material etc. etc. 

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