Purine ribonucleotide synthesis regulation

N4. Nierlich, D. P., and Magasanik, B., Regulation of purine ribonucleotide synthesis by end product inhibition. J. Biol. Chem. 240, 358-365 (1965). 

The activities of the enzymes of purine ribonucleotide interconversion can be both stimulated and inhibited in a variety of ways, and these potential control mechanisms may function not only to regulate the synthesis of ATP and of GTP, but also to maintain a balance in the relative intracellular concentrations of these two nucleotides. 

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