Pure Carbohydrate-induced Hyperglyceridemia

Following reports of triglyceride elevation in normal subjects on high carbo-hjrdrate diets, Ahrens et al. (1961) proposed that essential hyperlipemia may 

On the basis of our own experience and to some degree that of others, it seems probable that pure carbohydrate-induced hyperglyceridemia is a relatively rare entity, although by no means as rare as pure fat-induced hyperlipemia (hyperchylomicronemia). 

Data have now become available with regard to physical and chemical characteristics of the lipemic particles of carbohydrate-induced hyperlipemia (Ahrens et al. 1961, Bierman et al. 

The particulate fat which, on a fat-free diet, is obviously of endogenous origin, differs from alimentary particles in lipid composition (higher cholesterol/triglyceride ratio) and triglyceride fatty acid pattern (predominately palmitic, palmitoleic and oleic acids) as well as in protein content and physical characteristics. With the paper electrophoretic technic of Lees and Hatch (1963), carbohydrate-induced hyperlipemics appear to be characterized 

Recently, Kuo and Bassett (1965) have compared the effect of starch with that of sucrose in five patients with carbohydrate-induced hyperlipemia and observed significantly higher plasma triglyceride levels on the latter diet (see also page 451). 

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Fig. 3. Pure carbohydrate-induced byperglyce-ridemia (endogenous hyperglyceridemia group 1). Significant hyperglyceridemia was observed in this 47 year old male subject on a high carbohydrate, fat-free diet. Substitution of most of the carbohydrate by fat resulted in progressive fall in plasma glycerides to normal...

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