Puddle Jumping and Related Methods

In a recent development, Corcelli et al. [110] introduced a convenient bias function with general applicability that promises to accelerate the convergence of rate calculations in systems with large enthalpy barriers. They apply a puddle potential (used previously by the same group to enhance thermodynamic averaging [69]) that changes the potential energy surface from which the trajectories are initiated to become 

Unlike the methods mentioned above, the skewed momenta method involves accentuating the dynamics only along particularly relevant directions. Because the 

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