Pteroyl glutamic acid

Several quinoxaline analogs of pteroic acid (114) and pteroyl-glutamic acid (115) have been prepared. " - Quinoxaline-2-aldehyde,... 

N- (3,5-Dichloro-4 [ (2,4-diamino-6-pteridinyl) methyl] methylamino benzoyl) -L-glutamic acid, 4-amino-10-methyl-3, 5 -dichloro-pteroyl glutamic acid, NSC 29630. 

Synonyms cas 59-30-3 /-n-(p-(((-2-amino-4-hydroxy-6-pteridinyl) methyl>amino)BENZOYL)glutamicacid FOLACIN FOLATE FOLCYSTEINE PTEGLU PTEROYLGLUTAMC ACID PTEROYL-/-GLUTAMIC ACID PTEROYLMONOGLUTAMICACID PTEROYL-/-MONOGLUTAMIC ACID VITAMIN BC VITAMIN M... 

Pteroyl glutamic acid - folic acid (PteGlu) (FA)... 

Also among these derivatives is pteroyl-glutamic acid or folic acid, so called because of its abundant distribution in the leaves of plants. Folic add is the imiversal coenzyme for the transfer of Ci fragments and hence is indispensable for the s mthesis of purines and nucleic acids. 

The active form of fohc acid (pteroyl glutamate) is tetrahydrofolate (Figure 45-15). The folates in foods may have up to seven additional glutamate residues linked by y-peptide bonds. In addition, all of the one-carbon substituted folates in Figure 45-15 may also be present in foods. 

R12. Ross, J. F., Belding, H. W., and Paegel, B. L., Development and progression of subacute combined degeneration of spinal cord in patients with pernicious anemia treated with synthetic pteroyl glutamic (folic) acid. Blood 3, 68-90 (1948). 

Both pteroyl-a-glutamic acid and pteroyl-y-glutamic acid inhibit 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase. 

FoNc add (International generic name for iV-pteroyl-L-glutamic acid, PteGlu, coenzyme F). 

Folic acid (pteroyl-L-glutamic acid) the synthetic oxidized form of folate, found in supplements and added to fortified foods. 

This method of synthesis has been widely used in the preparation of folic acid derivatives, pteroic acid and related compounds. The fermentation factor (IV-pteroyl-di-y-L-glutamyl-L-glutamic acid) as well as fV-pteroyl-y-L-glutamyl-L-glutamic acid and other glutamyl conjugates of folic acid have... 

Subjecting pteroyl-di-y-glutamylglutamic acid and also pteroyl-y-glutamyl-glutamic acid to the steps used in s mthesis of foHnic acid resulted in three cmd two active compounds, respectively. Folinic acid was formed from each pteroyl derivative, and the corresponding di- and triglutamates which were separated chromatographically account for the other factors . 

---