Pteridines anticancer

A novel heterocyclic scaffold consisting of indole-fused pteridines has been obtained <05JCC813>. Several 2- and 4-substituted pteridines bearing different heterocycles in position 2 linked through a thioester group have been synthesized and claimed to be novel templates for anticancer chemotherapy <05BMC3513>. Parallel synthesis of pteridine derivatives as potent inhibitors for a hepatitis C virus RNA polymerase has been described <05BMCL675>... 

The development of 6-substitutcd pteridine-2,4-diamines and other related compounds has been important in the search for folate analogs as anticancer agents. The 6-carbon substituent may be incorporated in the pyrazine precursor (for example, see refs 149, 150) or be attached to the pteridine. The palladium-catalyzed coupling of alkynes with 6-chloropteridines has been very useful in this respect. The 6-chloropteridine 1 was coupled with a number of alkynes to yield the products 2.149... 

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