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Pt/C hydrogenation

DowPharma identified that selective hydrogenation of 179 with Pt-C will reduce the aldehyde moiety to 182, which is an intermediate for a potent nonpeptide gonadotropin-releasing hormone antagonist 183 by Merck (Scheme 12.74). Addition of an acid, either oxalic acid or D-tartaric acid, to the Pt-C hydrogenation will reduce the nitrile to 169, which is isolated as the salt.228,229... [Pg.236]

Hi, Pt/C Hydrogen, Platinum on Carbon 1333-74-0 7440-0 -4 7 7 7.2 Flammable. Relative cost expensive. Catalyst can be recycled. [Pg.76]

See other pages where Pt/C hydrogenation is mentioned: [Pg.5]    [Pg.205]   
See also in sourсe #XX -- [ Pg.202 ]



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C hydrogenation

C hydrogenative

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