Pseudolarix

In a very recent example, Chiu and co-workers (84-86) used the tandem ylide-cycloaddition methodology to prepare advanced intermediates directed toward the synthesis of the pseudolaric acids. Pseudolaric acids are a family of diterpenes isolated from the root bark of Pseudolarix kaempferi. These novel compounds have shown antimicrobial activity comparable to that of amphotericin B and have demonstrated cyctotoxicity against several cancer cell lines (Fig. 4.5). 

I eudolaric acids. Diterpenoids from the bark of Pseudolarix kaempferi, also known as Tujinpi in Chinese folk medicine, traditionally used against fungal skin infections. Besides the in vivo antifungal activity P. show in vitro cytotoxicity against several human tumor cell lines, the most effective sP. B (CjsHjgOg, Mr 432.46, cryst., mp. 165-167°C). 

Taxonomy Cycloartane Triterpenoids Pseudolarix kaempferi Gord. (Pinaceae) [1]. 

Pseudolaric acid B (Figure 8.2) is a member of the diterpene acids isolated from the extract of the root bark of Pseudolarix kaempfri Gordon. It exhibits... 

Pseudolaric acids, diterpenoids isolated from Pseudolarix kaempferi Gord., have been used in traditional Chinese... 

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