Pseudaxinyssa cantharella

Stevensine (17), which is related to oroidin (13) by oxidative cyclization, was isolated from an unidentified Micronesian sponge (43). The identical compound (17), named odiline, was obtained from aqueous extracts of a New Caledonian sponge, Pseudaxinyssa cantharella (44). This sponge also contained many other oroidin analogs dibromocantharelline [(+) -18], compounds 19, 20, 21, and (+)-dibromophakeline (22). The... 

Girolline (46), which is a potent cytotoxin isolated from the sponge Pseudaxinyssa cantharella, inhibits protein synthesis (2). 

The antitumor marine natural product girolline (35) has been isolated from the marine sponges Pseudaxinyssa cantharella and Axinella brevistyla. Treatment with girolline causes tumor cell lines to accumulate polyubiqui-tinated p53 but does not directly inhibit proteasome activity. Girolline may represent an interesting molecular probe of the ubiquitin-proteasome in tumor cells, since it is believed to prevent the recruitment of ubiquitinated proteins and may interfere with the function of adaptor proteins required for recruitment of polyubiquitinated proteins. 

De Nanteuil, G., Ahond, A., Guilhem, J., Poupat, C., Tran Hun Dan, E., Potier, P., Pusset, M., Pusset, J., Laboute, P., (1985). Marine invertebrates from the New Caledonian lagoon V Isolation and identification of metabolites of a new species of sponge, Pseudaxinyssa cantharella. Tetrahedron 41,6019-6033. 

Background the species Pseudaxinyssa cantharella is now Cymbastela canthardla. 

De Nanteuil, G Ahond, A Poupat, C., Potier, P., Pusset, M Pusset, )., and Laboute, P. (1985b) Invertebres marins du Lagon Neo-Caledonien- VI. Isolement et identification de onze sterols de type hydroxymethyl-3P-nor-A cholestane du spongiaire Pseudaxinyssa cantharella. Tetrahedron, 41,6035-6039. 

Recall that the species Cymbastela cantharella and Pseudaxinyssa canthardla are synonymous. 

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