Prulifloxacin Theophylline

Prulifloxacin reduced the elimination of theophylline in healthy volunteers (67) presumably by inhibiting cytochrome CYP1A2. 

Fattore C, CipoUa G, Gath G, Bertoh A, Orticelli G, Picollo R, MiUerioux L, Ciottoh GB, Perucca E. Pharmacokinetic interactions between theophylline and prulifloxacin in healthy volunteers. Chn Drug Invest 1998 16 387-92. 

Theophylline serum levels can be markedly increased in most patients by enoxacin. Pipemidic acid and clinafloxacin probably interact similarly. Theophylline levels can also be markedly increased in some patients by ciprofloxacin, and possibly pe-floxacin. Norfloxacin, ofloxacin, pazufloxacin, or prulifloxacin normally cause a much smaller rise in theophylline levels. However, serious toxicity has been seen in few patients given norfloxacin. Fleroxacin, flumequine, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, rufloxacin, spar-floxacin and trovafloxacin appear not to interact. 

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See also in sourсe #XX -- [ ]

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