Provocation inhalation challenge

Provocative Inhalation challenge has been used in an attempt to identify byssinogenic agents (52-54, 83-86). Results of these studies have been Inconclusive, but most positive reactions appear to be due to endotoxin contamination of the dust, or to a toxic or irritant factor (52,53). 

Munn A (1965) Hazards of isocyanates. Ann Occup Hyg 8 163-169 Newman-Taylor AJ, Davies RJ, Hendrick DJ, Pepys J (1979) Recurrent nocturnal asthmatic reactions to bronchial provocation tests. Clin Allergy 9 213-220 O Brien IM, Harries MG, Burge PS, Pepys J (1979 a) Toluene di-isocyanate-induced asthma. 1 Reactions to TDI, MDI, HDI, and histamine. Chn Allergy 9 1-6 O Brien IM, Newman-Taylor AJ, Burge PS, Harries MG, Fawcett IW, Pepys J (1979b) Toluene di-isocyanate-induced asthma. 2 Inhalation challenge tests and bronchial reactivity studies. Clin Allergy 9 7-15... 

The accurate diagnosis of AIA can be established by oral, inhaled, nasal or intravenous placebo-controlled provocations tests with increasing doses of aspirin [10], There is no reliable in vitro test. Oral challenges are most commonly performed, because the oral route mimics natural exposure and the test does not require special equipment, except simple spirometry. The threshold dose of aspirin which provokes a 20% fall in FEVi (positive reaction) will vary with individual patients, depending... 

The promising animal studies with lodoxamide tromethamine led to its investigation in hunan subjects. TVio independent broncho-provocation studies in patients with extrinsic bronchial asthma have been reported. Moreno and LeZotte (24) studied 12 j tients, who had been pretreated randomly with inhaled lodoxamide tromethamine (1.0 mg, 0.1 mg, 0.01 mg) or placebo in a double blind manner, in a standard bronchial challenge. Each of the j tients was treated with each drug dose and placebo in separate settings... 

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