Proton transfer reaction mass spectrometry medical

Lindinger, W., Fall, R., Karl, T.G. (2001) Environmental, food and medical applications of proton-transfer-reaction mass spectrometry (PTR-MS). Adv. Gas Phase Ion Chem. 4 1-48. 

Zhan, X., Duan, J., Duan, Y. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research. Mass Spectrom. Rev. 32, 143-165 (2013)... 

ENVIRONMENTAL, EOOD AND MEDICAL APPLICATIONS OF PROTON-TRANSFER-REACTION MASS SPECTROMETRY (PTR-MS)... 

The development of proton-transfer-reaction mass spectrometry (PTR-MS) as a tool for the analysis of volatile organic compounds (VOCs) is described. PTR-MS is based on the rapid, non-dissociative transfer of protons from H30 to most common VOCs, but not to the principal gases in the air sample. Recent developments in the design of PTR-MS instruments allow detection of some VOCs in the parts per trillion by volume range. This sensitivity and the capability of PTR-MS instruments to be operated for extended periods in both laboratory and field settings has allowed exploration of many aspects of VOC analysis in environmental, food and medical applications. 

We have briefly mentioned the use of data on IMR in plasma modeling and for the understanding of interstellar molecular synthesis as well as of ionospheric chemistry, and we also want to point out the applications of IMR in various methods of chemical ionization. The most recent one, developed in our laboratory, namely proton-transfer reaction mass spectrometry (PTR-MS), allows for on-line monitoring of volatile organic compounds at levels as low as a few parts per trillion and is therefore applicable for environmental, food, and medical research involving investigations of fast metabolic and enzymatic processes. 

The book concentrates on the most common instruments nsed in chemical, environmental, biological, and medical research. Less frequently encountered forms of mass spectrometry are not addressed, such as inductively coupled plasma mass spectrometry (ICP-MS) isotope ratio mass spectrometry (IRMS), accelerator mass spectrometry (AMS), proton transfer reaction mass spectrometry (PTRMS), and single-particle laser ablation time-of-flight mass spectrometry (SPLAT). 

Lindinger,W., Hansel, A., Jordan,A. (1998) On-hne monitoring of volatile organic compounds at pptv levels by means of proton-transfer-reaction mass spectrometry (PTR-MS)—medical appMcations, food control and environmental research. International Journal of Mass Spectrometry, 173,191-241. 

Wang, Y.J., Han, H.Y., Shen, C.Y, Li, J.Q., Wang, H.M., Chu,Y.N. (2009) Control of solvent use in medical devices by proton transfer reaction mass spectrometry and ion molecule reaction mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 50, 252-256. 

Lindinger, W. Hansel, A. Jordan, A. Online Monitoring of Volatile Oiganic Compounds at Pptv Levels by Means of Proton-Transfer-Reaction Mass Spectrometry (PTR-MS). Medical Applications, Food Control and Environmental Research. Int. J. Mass Spectrom. Ion Proc. 1998, J7J, 191-241. 

Lirk, R, Bodrogi, F., Rieder, J. (2004) Medical applications of proton transfer reaction-mass spectrometry ambient air monitoring and breath analysis. Int. J. Mass Spectrom. 239, 221. 

Thompson, X, Worthington, T. (2004) The proton transfer reaction mass spectrometer and its use in the medical sciences applications to drug assays and the monitoring of bacteria. International Journal of Mass Spectrometry, 239, 235-241. 

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