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Proton pump inhibitors 2780 INDEX

CANNABIS PROTON PUMP INHIBITORS-OMEPRAZOLE, LANSOPRAZOLE Unpredictable changes in plasma concentration. Risk of toxicity or therapeutic failure, particularly of drugs with a narrow therapeutic index Induction or inhibition of CYP3A4-mediated metabolism by cannabis. It is not yet known whether the effects are dependent on the degree of cannabis consumption Be aware. Watch for signs of toxicity, especially when cannabis use abruptly changes... [Pg.699]

Delavirdine Due to its shorter tj, d rapid emergence of resistance, delavirdine is the least used of the NNRTIs. Its absorption is best at acid pH and may be decreased by histamine Hj receptor antagonists or proton pump inhibitors. It is cleared predominantly by CYP3A4 and has an elimination tj 6 hours. It should be avoided with CYP3A4 substrates with a narrow therapeutic index and not combined with potent inducers of CYP3A4 (e.g., carbamazepine, phenobarbital, phenytoin, rifabutin, and rifampin). [Pg.847]

In a case-control study, nested in a retrospective cohort study, of the combined risk of serious ventricular dysrhythmias and sudden cardiac death in domperidone users, compared with users of proton pump inhibitors or non-users of these medications, up to four control subjects were matched to each case by index date, year of birth, sex, and diabetes status [8 ]. From 83212 individuals in the exposure cohort, 1608 cases were identified, including 49 with serious ventricular dysrhythmias and 1559 sudden cardiac deaths (mean age 79 years, women 53%, diabetes 22%). The adjusted odds ratio for serious ventricular dysrhythmias and sudden cardiac death with domperidone compared with non-use was 1.6 (95% CI=1.3, 2.0) compared with proton pump inhibitors the QR was 1.4 (95% Cl = 1.1, 1.9). In stratified analyses, adjusted odds ratios were higher in men, older subjects, and non-diabetics. [Pg.556]


See other pages where Proton pump inhibitors 2780 INDEX is mentioned: [Pg.101]    [Pg.278]   
See also in sourсe #XX -- [ Pg.1653 ]




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