Proton gating mode

Baker In the DRG, one mode shifter appeared to be change in pH, in as much as late current is very sensitive to acidification (Baker Bostock 1999). If you acidify, the late currents disappear. In part, this seems to be due a change in gating rather than just simply proton block. I would suggest that pH is one way in which gating mode can be modulated. 

Proton transfer is coupled to the dynamics of two nuclear mode sets with widely different timescales, viz. the proton modes themselves and the environmental protein conformational and external solvent modes. The proton is trapped at the donor fragment at the equilibrium environmental conformational/solvent configuration in the reactants state, but fluctuations in these nuclear coordinates induce a state of resonance between the proton vibrational levels in the reactants and products states. Environmental gating modes with their special status in proton transfer are parts of this process. 

Peak Areas The areas of NMR peaks are not necessarily proportional to the number of carbons giving rise to the peaks. Carbon atoms with two or three protons attached usually give the strongest absorptions, and carbons with no protons tend to give weak absorptions. Newer spectrometers have an integrating mode that uses gated... 

The spectra were measured on a VARIAN XL-100-12 spectrometer in the FT mode using V-4410 and V-4418 probe heads with 10 and 18 mm inserts, respectively. The instrument is equipped with an SL-124 computer station including a disk system. Proton-coupled spectra were obtained under gated... 

Spectroscopic Measurements. and NMR spectra were obtained on either a Bruker AC-250 or an AM-360 spectrometer operating in the FT mode. Si NMR spectra were recorded on an IBM Bruker WP-270-SY spectrometer. Five percent w/v solutions of copolymer in chloroform-c/ were used to obtain NMR spectra. NMR spectra were run with broad band proton decoupling. A heteronuclear gated... 

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