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Proton-coupled folate transporter

Table 44.3 Affinities of folate receptor, reduced folate carrier and proton-coupled folate transporter for folate (oxidized and reduced form) and antifolate. Table 44.3 Affinities of folate receptor, reduced folate carrier and proton-coupled folate transporter for folate (oxidized and reduced form) and antifolate.
Folate Folate receptor Reduced folate carrier Proton-coupled folate transporter... [Pg.770]

Yokooji, T., Mori, N., and Murakami, T., 2009. Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. Journal of Pharmacy and Pharmacology. 61 911-918. [Pg.785]

Zhao, R., and Goldman, I.D., 2007. The molecular identity and characterization of a Proton-coupled Folate Transporter-PCFT biological ramifications and impact on the activity of pemetrexed. Cancer and Metastasis Reviews. 26 129-139. [Pg.785]

Figure 4-4. Intestinal absorption of dietary folates (THF-[Gluy and foUc acid (F) from fortified cereal products and vitamin supplements. In the duodenum and upper jejunum, extra glutamate residues are cleaved by conjugases (y-glutamyl carboxypeptidases). Folate (F) and reduced folate (THF) are absorbed by a proton-coupled, high affinity folate transporter into the mucosal cell, converted to N -methyl THF and exported into the portal circulation. N -methyl THF is taken up into cells by facilitative diffusion, converted to THF by the Bj -requiring methionine synthase and then converted to a polyglutamate. Figure 4-4. Intestinal absorption of dietary folates (THF-[Gluy and foUc acid (F) from fortified cereal products and vitamin supplements. In the duodenum and upper jejunum, extra glutamate residues are cleaved by conjugases (y-glutamyl carboxypeptidases). Folate (F) and reduced folate (THF) are absorbed by a proton-coupled, high affinity folate transporter into the mucosal cell, converted to N -methyl THF and exported into the portal circulation. N -methyl THF is taken up into cells by facilitative diffusion, converted to THF by the Bj -requiring methionine synthase and then converted to a polyglutamate.
See other pages where Proton-coupled folate transporter is mentioned: [Pg.769]    [Pg.782]    [Pg.84]    [Pg.769]    [Pg.782]    [Pg.84]   


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