Protoanemonin degradation

Blasco R, M Mallavarapu, R-M Wittich, KN Timmis, DH Pieper (1997) Evidence that formation of protoanemonin from metabolites of 4-chlorobiphenyl degradation negatively affects the survival of 4-chlorobiphenyl-cometabolizing microorganisms. Appl Environ Microbiol 63 434. 

Additional limitations. Other limitations have been enconntered (a) the formation of the inhibitory protoanemonin from 4-chlorocatechols (Blasco et al. 1995) and (b) the ineffectiveness of cycloisomerases reqnired for effective degradation of 2-chlorotoluene (Polhnann et al. 2005). An example of this limitation is given later, and in the degradation of 3-flnorobenzoate in Part 3 of this chapter. 

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