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Prothrombin activator intrinsic, formation

The last step of the formation of intrinsic thromboplastin concerns the conversion of product II to the intrinsic thromboplastin or intrinsic prothrombin activator. The present concept is that product II (a phospholipid) reacts with factor V (a protein) to yield an active lipoprotein. Little is known of product II. Also, it has been claimed to possess esterase activity. [Pg.401]

Both intrinsic and extrinsic pathways generate activated factor X. This protease, in turn, catalyses the proteolytic conversion of prothrombin (factor II) into thrombin (Ha). Thrombin, in turn, catalyses the proteolytic conversion of fibrinogen (I) into fibrin (la). Individual fibrin molecules aggregate to form a soft clot. Factor XHIa catalyses the formation of covalent crosslinks between individual fibrin molecules, forming a hard clot (Figures 12.3 and 12.4). [Pg.332]

See other pages where Prothrombin activator intrinsic, formation is mentioned: [Pg.853]    [Pg.616]    [Pg.87]    [Pg.3]    [Pg.30]    [Pg.136]    [Pg.176]    [Pg.3]    [Pg.3]    [Pg.193]    [Pg.218]    [Pg.186]    [Pg.25]    [Pg.163]    [Pg.664]    [Pg.1497]    [Pg.131]    [Pg.158]    [Pg.1213]    [Pg.567]    [Pg.513]    [Pg.257]    [Pg.266]    [Pg.580]    [Pg.205]    [Pg.580]    [Pg.158]   
See also in sourсe #XX -- [ Pg.3 ]



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Prothrombin activation

Prothrombin activator

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