PROTEOMICS - RELATION TO GENOMICS, BIOINFORMATICS

In humans, about 30,000 genes are responsible for making approximately 500,000 proteins. It is indeed a challenge to determine how such a small number of genes can make so many proteins. Much of the change in protein profile is generated by the alternate splicing of transcripts and posttransla-tional modification of proteins. 

Introduction to Proteomics Principles and Applications, By Nawin C. Mishra Copyright 2010 John Wiley Sons, Inc. 

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Explain the importance of bioinformatics in relation to proteomics and genomics. 

Similarly, we have described how information related to protein-splicing variants, amino acid peptide variants (polymorphisms), and PTMs is being introduced in data analysis pipelines in order to increase the rate of identifiable peptides. The introduction of genomics and transcriptomics information, often neglected in routine proteomics analyses, will enable the characterization of myriad splicing variants and amino acid polymorphisms, as well as the development of robust proteomics analysis pipelines, which will contribute to elucidate their role in health and disease states. These tools will make it possible to uncover a new layer of the proteome complexity and to expand the information available from cellular systems and the potential implication of these protein variants in different physiological processes. Finally, several bioinformatics tools that perform unbiased PTM analysis have also been reviewed. The tools that are currently being developed and refined tackle... 

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