Proteomics Approaches in Animal Intervention Studies

A rat model of oxidative stress was used to investigate the mechanism(s) whereby salicylic acid modulates potentially procancer-ous activity in the colon using a proteomic approach. Supplementation of salicylic acid (1 mg/kg diet) resulted in a significant change in expression of 55 cytosolic proteins extracted from the distal colon milled in liquid nitrogen. The functions of these proteins related to protein folding, protein transport, redox balance, energy metabolism, and [Pg.139]

PROTEOMICS AS A TOOL TO TEST EFFICACY OF FUNCTIONAL FOODS [Pg.142]