Proteome informatics

Wojcik, J. and Hamburger, A. (2003) Proteomic Informatics. In Bioinformatics for Geneticists. 

Fig. 4. Application of bioinformatics tools to 2D-DIGE data analysis. Proteome data consisting of the normalized spot intensity values are exported from the image analysis software and their correlation with clinicopathological data examined. Using informatics tools including clustering algorithms and machine-learning methods, a novel cancer classification based on proteome data is established, and key proteomic features and proteins corresponding to biomarker candidates are identified.

Radulovic D, Jelveh S, Ryu S, et al. Informatics platform for global proteomic profiling and biomarker discovery using liquid-chromatography-tandem mass spectrometry. Mol Cell Proteomics 2004 21 21. 

Augen, J., 2005, Bio informatics in the post-genomic era Genome, transcriptome, proteome, and information-based medicine, Addison-Wesley. 

SciNova Informatics, an Indian company, has developed a data mining product Prometheus targeted towards genomics, proteomics and small molecule research In Life Sciences. 

Functional Genomics Informatics for Proteins Proteomics Systems Biology... 

Other library-based approaches (such as GMF) would benefit from free availability of databases, containing structural information as well as spectrometric data. The use of widely available free databases would enhance the use of informatics in glycomics to a level comparable to proteomics, where the use of databases is part of daily work in nearly all laboratories. 

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