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Proteolytic inhibitors, assay

J.O. Capobianco, C.G. Lerner, and R.C. Goldman, Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase, Anal. Biochem., 204, 96, 1992. [Pg.116]

As mentioned above, assay readouts based on fluorescence are probably the most commonly used of all HTS detection techniques. A number of different flavors of fluorescence-based assays exist. The simplest one, called fluorescence intensity (FLINT) was used, for example, to assay for inhibitors of a proteolytic enzyme that releases a fluorescent component upon cleavage of a specially designed substrate, as shown in Figure 6.3. In this case the enzyme of interest is Cathepsin K, a cysteine protease critical to bone resorption, inhibitors of which are of interest to fight osteoporosis. ... [Pg.223]

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Proteolytic

Proteolytic inhibitors

Proteolytic inhibitors, assay activities

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