Proteoglycans biosynthesis

An important question in proteoglycan biosynthesis is how different GAGs (DS, CS, HS, and heparin) are assembled starting from the common tetrasaccharide structure. The precise molecular mechanisms, namely, whether it is the... 

A new synthetic route towards naphthyl xylosides was performed on solid support. Pure xylosides were obtained in 6-42% overall yield from the amino-methylated resin [84, 85], Similarly, p-o-xylopyranosides bearing a fluorescent moiety as a probe for proteoglycan biosynthesis [83], bis-xylosylated dihydrox-ynaphthalenes [86] and 2-naphthyl-l-thio-P-o-xylopyranosides were also prepared and these compounds have exhibited a strong pruning of GAG chains biosynthesis [87]. 

Quentin-Hoffmann E, Harrach B, Robenek H, Kresse H. Genetic defects in proteoglycan biosynthesis. Padiatr Padol 1993 28 37-41. 

Deductions concerning the loci of proteoglycan biosynthesis come om a considerable amount of work involving radioactive labeling of proteoglycans in vitro and autoradiography of the labeled tissue, and from investigation of a number of induced effects upon biosynthesis— some of such work has been reviewed (S46). 

Hauselmann HJ, Oppliger L, Michel BA et al. Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture. FEBS Lett 1994 352 361-4. 

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