Proteins, interaction with platinum agents

INTERACTION OF PLATINUM AGENTS WITH AMINO ACIDS, PEPTIDES AND PROTEINS... 

So, in principle, we have to consider three types of species, all competing for cisplatin, namely, the rescue agents, the peptides and proteins, and the DNA. Although, at present, much highly relevant information is available about Pt-DNA binding, information of other aspects of in vivo platinum chemistry has become recently available [18-20], A review devoted towards the interaction of (new, active, and some relevant inactive) platinum compounds (in model fluids in vitro and in vivo) with cellular components (DNA peptides) and additives (rescue agents) is highly relevant and timely, and the most important results available will be discussed below. 

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