Protein theory

Protein Theories. The direct interaction of inhalation anesthetics and proteins has been proposed as the cause of anesthesia. An inhalation agent, whether a noble gas or a fluorinated ether, could dissolve asymmetrically in a protein, Resultant conformational changes in the protein, if these changes occur, could then cause changes in biological activity. 

Peoples RW, Li C, Weight F. 1996. Lipid vs protein theories on alcohol action in the nervous system. Annu Rev Pharmacol Toxicol 36 185-201. 

Protein family used to describe a protein family database. See Persson, B., Bioinformatics in protein analysis, EXS 88, 215-231, 2000 Bateman, A., Bimey, E., Cerruti, L. et al., The Pfam protein families database, Nucl. Acids Res. 30, 276-280, 2002 Lubec, G., Afjehi-Sadat, L., Yang, J.W., and John, J.P, Searching for hypothetical proteins theory and practice based upon original data and literature, Prog. Neurobiol. 77,90-127,2005 Anderston, J.N., Del Vecchio, R.L., Kannan, N. et al., Computational analysis of protein tyrosine phosphatases practical guide to bioinformatics and data resources, Methods 35, 90-114, 2005. 

Another common theory of formation for stream and soil humic substances is a modified remnant of the old ligno-protein theory of Waksman 11938). This theory states that soil and stream humic substances are degradation products of lignin from terrestrial plants which are composed primarily of lignin and celluloses. This theory has been especially promoted by many... 

Chemically, general anaesthetics are a diverse group of drugs they are all small lipid soluble molecules, but their mechanism of action is unknown. However, there are two main theories to explain the mechanism of action of general anaesthetics. These are the lipid theory and the protein theory. 

The protein theory is currently considered more likely to explain the process of anaesthesia, because general anaesthetics affect synaptic transmission rather than axonal conduction. Both the release of transmitter and the response of the postsynaptic receptors are affected. 

The mechanism of action of general anaesthetics is unknown, but there are two theories to explain their action the lipid theory and the protein theory. The lipid theory states that general anaesthetics interact with lipids in the neuronal cell membrane and disrupt neurotransmission and the protein theory states that general anaesthetics interact with membrane proteins to alter release of neurotransmitters. The protein theory is thought most likely. 

Integral proteins could provide a large contribution to the curvature-induced membrane polarization. Both dipolar and quadrupolar contributions could show up, more pronounced than those of lipids. The reason for such an expectation is the very large dipole moment measured for some proteins. Theory also demonstrates that such big molecules with no spherical symmetry may have a very large anisotropy of the quadrupole moment. 

Hermens, W.T., Willems, G.M. and Visser, M.P. (1982) Quantification of Circulating Proteins Theory and Applications Based on Analysis of Plasma Protein Levels, Martinus Nijhoff, The Hague. 

An interesting and elusive candidate for electron transfer studies is the Sulfite Oxidase protein [143], For this protein, theory predicts an electron transfer rate between the cofactors (a heme and a molybdenum complex) about two orders of magnitude lower than what is measured experimentally [2], To address this issue, Beratan et. al., using the Pathways model, suggested that the donor and the acceptor are joined together by a flexible tether [144], As the tether allows the two cofactors to come sufficiently close to each other, electron transfer occurs at the rate shown by experiment. A recent simulation of this mechanism was carried out so that the protein was taken out of equilibrium and positioned in a new folded state featuring a much... 

The effect of activator on the thermal stability of protein - Theory... 

M. Nonella and K. Schulten. Molecular dynamics simulation of electron transfer in proteins — theory and application to Qa Qb transfer in the photosynthetic reaction center. J. Phys. Chem., 95 2059-2067, 1990. 

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