Protein synthesis inhibitors initiation

The soybean GH3 clone was initially isolated by differential hybridization screening as an auxin-induced cDNA clone from etiolated hypocotyls [9]. Nuclear run-on experiments have shown that transcription of the GH3 gene is induced within 5 minutes after auxin treatment of excised soybean plumules [20]. The soybean GH3 gene is specifically induced by biologically active auxins. Unlike SAURs and Aux/IAA mRNAs, GH3 mRNAs do not accumulate in response to protein synthesis inhibitors like cycloheximide... 

Other inhibitors of protein synthesis - The initial finding that fusidic acid inhibits protein synthesis by specifically blocking the step of translocation at the level of the bacterial ribosome was also confirmed using ribosomes of the 80 S type. It has been found recently that the antibiotic does not inhibit formation of the ribosome-G factor-GDP complex . On the other hand, cycloheximide and streptovitacin A were found to inhibit specifically protein synthesis only by 80 S ribosomes. The antibiotics, block the translocation step by inactivating the enzyme involved in it O. e... 

Linezohd (Zyvox) is an oxazolidinone, a tive-membered heterocychc ring that forms the core of the hnezohd structure. The approval of hnezohd by the FDA in 2000 marked the first new structural class of antibacterial introduced into medical practice in the United States in 40 years. It is notable for its activity against methicillin-resistant Staph aureus, MRSA, and vancomycin-resistant Enterococcus faecium, VRE. It is bacteriostatic rather than bactericidal but finds significant use in patients with an intact immune system. Like several other classes of antibacterials, linezolid is an inhibitor of protein synthesis. It interacts specifically with the RNA component of a bacterial ribosome subunit to prevent initiation of protein synthesis. 

Many experimental results have confirmed the chemical basis of memory. For example, learning is facilitated by administration to animals of small doses of strychnine.1015 Puromycin and other inhibitors of protein synthesis disrupt the transfer of information into long-term memory. They are especially effective during the first hour after the initial learning event.1016 Increased synthesis both of mRNA and of proteins within the cell bodies of neurons is observed. 

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