Protein synthesis, antibacterial drug tetracyclines

Antibacterial drugs that affect bacterial protein synthesis include the aminoglycosides, tetracyclines, macrolides, and the single drug chloramphenicol. 

Antibacterial drugs that inhibit protein synthesis aminoglycosides, tetracyclines, macrolldes and chloramphenicol... 

Tetracyclines This very successful class of antibacterials act selectively on the bacterial ribosome inhibiting protein synthesis. They do not bind with mammalian ribosomes in the cytoplasm and, therefore, do not have a direct effect on the patient s metabolism. Like any drug, they are not free of potentially harmful side effects. They complex calcium and can interfere with development of the permanent teeth prior to their erupting through the gums As with the sulfonamides, this class... 

Tetracyclines, like doxycycline, are broad-spectrum antibiotics with extended use as cheap and effective antibacterials. They act at the level of protein synthesis, and impair, in case of Plasmodium fakiparum, the formation of mero-zoites. Due to a slow onset of activity, doxycycline is used in combination with faster acting drugs for malaria therapy as a single compound it is today applied in prophylaxis, frequently in regions with known chloroquine resistance. 

The ability of streptomycin, under certain conditions, to induce misreading of the genetic code and to produce nonsense polypeptides, may be phenomena of the laboratory unrelated to the clinical use of this drug (Luzzatto, Apirion, and Schlessinger, 1968). Streptomycin is lethal to cells only when they are vigorously engaged in protein synthesis. For this reason, some other inhibitors of protein synthesis, notably chloramphenicol and tetracycline, interfere with the antibacterial action of streptomycin. 

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