Protein Properties Correlating with Half-Lives

Protein Properties Correlating with Half-Lives 

Attempts to explain the diversity of protein half-lives and relate them to biological function have resulted in a number of highly significant correlations being discovered (Bohley, 1968 Goldberg and St. John, 1976 Ballard, 1977). In general, these relationships apply to intracellular proteins from several tissues, but most information has been obtained from rat liver. Thus proteins with the shortest half-lives in vivo have the following characteristics  

The largest subunit molecular weights. This also applies to individual enzymes, at least in rat liver. 

More acid isoelectric points. A similar correlation was found when the isoelectric points of liver enzymes were compared to their half-lives. 

The highest proportion of surface hydrophobic regions. Proteins which had short half-lives in vivo showed selective movement to the organic phase in partition experiments between aqueous solution and CCI4, isobutanol, xylol, oleic acid, benzene, or liver lipids. 

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F. Protein Properties Correlating with Half-Lives... 

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