Protein phosphatases classification

Protein Phosphatases. Figure 3 Classification of protein tyrosine phosphatases. See text for details. Common names for selected PTPs are used according to Ref. [2]. 

Ingebritsen TS, Cohen P (1983) The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities. Eur J Biochem 132 255-261... 

Table 17-1 Historical classification and properties of serine/threonine protein phosphatases... 

A machine-learning method was proposed by Klon et al. [104] as an alternative form of consensus scoring. The method proved unsuccessful for PKB, but showed promise for the phosphatase PTPIB (protein tyrosine phosphatase IB). In this approach, compounds were first docked into the receptor and scored using conventional means. The top scoring compounds were then assumed to be active and used to build a naive Bayes classification model, all compounds were subsequently re-scored and ranked using the model. The method is heavily dependent upon predicting accurate binding... 

Patankar, S.J. and Jurs, P.C. (2003b) Classification of inhibitors of protein tyrosine phosphatase IB using molecular structure based descriptors. 

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