Protein Mediated DNA Biosensors

Palecek et al. [64] and Masarik et al. [65] detected a G-T mismatch at CPE and HMDE using chronopotentiometric stripping analysis (CSA) and squarewave voltammetry (SWV) in the presence of MutS. Cho et al. [66] found that the binding affinity of MutS for 

Electrochemical impedance measurements in the presence ]3-/4- Qf j-gj matched and [c] single mismatched ds-DNA films [b] and [d] schematically represent MutS interactions with matched and mismatched films, respectively. Please note the significant increase in the impedance signal as a function of MutS bound to the surface, causing a significant increase in the charge transfer resistance. C.-Z. Li, Y.-T. Long, J. S. Lee, and H.-B. Kraatz, Chem. Commun., 2004, 574-575. Reproduced by permission of the Royal Society of Chemistry. 

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