Protein nonhydrolytic enzyme-catalyzed

Table II. Enzyme-Catalyzed Nonhydrolytic Modifications of Proteins...

For the purpose of this chapter, enzyme-catalyzed modifications of proteins will be divided into two groups hydrolytic and nonhydrolytic reactions. Generally speaking, post-translational reactions occurring in vivo are catalyzed by highly specific enzymes under rather restricted conditions in contrast with in vitro modifications which are carried out under less specific conditions. 

A third enzyme, ADP-ribosyl protein lyase, catalyzes the nonhydrolytic cleavage of protein proximal ADPR residues yielding the unique nucleotide ADP-3"-deoxy-pentos-2"-ulose (ADP-DP). In addition to the basic enzymology shown in Figure 1, related enzyme activities... 

More structural data for cellulose-type linkage geometries are available from crystals of proteins that are complexed with either cellulose fragments or molecules that contain a lactose moiety. Figure 15-10 shows a complex of cellotetraose and an endoglucanase (Sakon et al. 1996), as well as the structure of the fragment in more detail. That protein is an enzyme that catalyzes the hydrolysis of cellulose molecules, but it also has nonhydrolytic binding sites. Other proteins do... 

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