Engrailed homeodomain protein

Figure 5 The overlay of the backbones of designed protein (black) and wild-type (gray) engrailed homeodomain, pdb code lenh (25).

Adaptability at a protein-dna interface re-engineering the engrailed homeodomain to recognize an unnatural nucleotide,/. Am. Chem. Soc. 2004, 126(26), 8078-9. 

Fig. 7.11 The engrailed homeodomain (En-HD) protein contains three short helical segments.

Han K, Jeon MJ, Kim KA, Park J, Choi SY. Efficient intracellular delivery of GFP by homeodomains of Drosophila Fushi-tarazu and Engrailed proteins. Mol Cells 2000 10 728-32. 

Peltenburg, L., Murre, C. 1996. Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in PBX. The EMBO J. 15, 3385-3393. 

Peltenburg, L.T.C., Murre, C. 1997. Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteins. Development 124, 1089-1098. 

Fig. 2. A. Domain structure of Msx proteins (after Hu et al., 1998). Ehl is a repressor domain shared by engrailed and a number of other homeodomain-containing proteins (Smith and Jaynes, 1996). B. Mutations in Msx2 homeodomain that engender human diseases. Data from Jabs et al. (1993) and Wilkie et al. (2000). (See Color Insert.)...

---