Engrailed homeodomain

Both domains of the POU region bind to DNA by the usual combination of non specific binding to the DNA backbone and specific binding to the bases. The contacts between the homeodomain and DNA are similar to those of the engrailed homeodomain (compare Figures 9.10b and 9.15a) and the... 

Kissinger, C.R., et al. Crystal structure of an engrailed homeodomain DNA complex at 2.8 A resolution a framework for understanding homeodomain-DNA interactions. Cell 63 579-590, 1990. 

Human (Homo sapiens) Escherichia coli Aspergillus awamori, variant xlOO engrailed Homeodomain Drosophila melanogaster... 

Figure 5 The overlay of the backbones of designed protein (black) and wild-type (gray) engrailed homeodomain, pdb code lenh (25).

Zhao X, Huang X, Sun C. Molecular dynamics analysis of the engrailed homeodomain-DNA recognition. J. Struct. Biol. 2006 155 426-437. 

Helix-turn-helix eukaryotic engrailed homeodomain 2.8 [107]... 

Adaptability at a protein-dna interface re-engineering the engrailed homeodomain to recognize an unnatural nucleotide,/. Am. Chem. Soc. 2004, 126(26), 8078-9. 

Fig. 7.11 The engrailed homeodomain (En-HD) protein contains three short helical segments.

Figure 2 Demonstration of microscopic reversibility for the (a) chymotrypsin inhibitor 2 (CI2) and (b) engrailed homeodomain (EnHD). In both (a) and (b) the top unfolding pathways traverse conformational states that are revisited on the lower folding pathways illustrating the equality of the unfolding and refolding pathways.

Figure 8 Refolding of the engrailed homeodomain (EnHD) using the quench method...

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