Protein dynamics biological processes

For 25 years, molecular dynamics simulations of proteins have provided detailed insights into the role of dynamics in biological activity and function [1-3]. The earliest simulations of proteins probed fast vibrational dynamics on a picosecond time scale. Fifteen years later, it proved possible to simulate protein dynamics on a nanosecond time scale. At present it is possible to simulate the dynamics of a solvated protein on the microsecond time scale [4]. These gains have been made through a combination of improved computer processing (Moore s law) and clever computational algorithms [5]. 

Proteins are the most abundant of cellular components. They include enzymes, antibodies, hormones, transport molecules, and even components for the cytoskeleton of the cell itself. Proteins are also informational macromolecules, the ultimate heirs of the genetic information encoded in the sequence of nucleotide bases within the chromosomes. Structurally and functionally, they are the most diverse and dynamic of molecules and play key roles in nearly every biological process. Proteins are complex macromolecules with exquisite specificity each is a specialized player in the orchestrated activity of the cell. Together they tear down... 

Schlag EW, Yang D-Y, Sheu S-Y, Selzle HL, Rentzepis PM (2000) Dynamic principles in biological processes a model of charge migration in proteins and DNA. Proc Nat Acad Sci USA 97 9849-9854... 

Large multiprotein complexes often participate in ET reactions but are also responsible for many other biological processes. Currently, the design of photoactive reagent, which would cross-link the associated proteins, seems to be a promising method for probing the dynamics of protein-protein interactions [107-111], The... 

EXAMPLES HIGHLIGHTING THE ROLE OF PROTEIN INTERNAL DYNAMICS IN BIOLOGICAL PROCESSES... 

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