Protein-coding genes transcription factor binding sites

The various transcription-control elements found in eukaryotic DNA are binding sites for regulatory proteins. In this section, we discuss the identification, purification, and structures of these transcription factors, which function to activate or repress expression of eukaryotic protein-coding genes. 

The TATA box-binding protein (TBP) is a basic transcription factor absolutely required for transcription by the three nuclear RNA polymerases (7). RNA polymerase II transcription of many protein coding genes requires direct contact of the DNA by TBP, at a sequence called the TATA box, which is located approximately 30 basepairs upstream of the transcription initiation site (2). This complex directs the assembly of the remaining basic transcription factors into a preinitiation complex (i). 

Genes include the regions of DMA that code for a particular protein or polypeptide, as well as regions of DMA used to control the rate of transcription. Please find the binding site for a transcription factor on this region of the leptin gene ... 

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