Protein catenane synthesis

Peptide ligation strategies used so far have mainly been used for protein total synthesis and protein engineering purposes. The ability to prepare perfectly mono-disperse and relatively high molar mass peptides with precise control over the a-amino acid sequence could also afford unprecedented opportunities for the development of novel biologically-inspired supramolecular architectures and materials. As a final, recent, example, the preparation of a protein[2]catenane using NCL is shown in Figure 6.6.5 [34]. 

Fig. 10.2-12 Synthesis of a protein catenane based on the p53 tetramerization domain.

Fig. 6.6.5. Synthesis of a protein[2]catenane using native chemical ligation. (Adapted from Ref. [34]).

---