Protection for the Phosphate Group

SOME GENERAL METHODS FOR PHOSPHATE ESTER FORMATION REMOVAL OF PROTECTIVE GROUPS FROM PHOSPHORUS 

2-(2 -Pyridyl)ethyl, 677 2-(4 -Pyridyl)ethyl, 677 2-(3-Arylpyrimidin-2-yl)ethyl, 677 2-(Phenylthio)ethyl, 678 2-(4 -Nitrophenyl)thioethyl, 678 2-(4 -Triphenylmethylphenylthio)ethyl, 678 2-[2 -(Monomethoxytrityloxy)ethylthio]ethyl, 678 Dithioethanol Derivative, 679 2-(f-Butylsulfonyl)ethyl, 679 2-(Phenylsulfonyl)ethyl, 679 2-(Benzylsulfonyl)ethyl, 679 

0- Nitrobenzyl, 684 4-Nitrobenzyl, 685 2,4-Dinitrobenzyl, 685 4-Chlorobenzyl, 685 4-Chloro-2-nitrobenzyl, 685 

1- Oxido-4-methoxy-2-picolyl, 685 Fluorenyl-9-methyl, 686 Pyrenylmethyl, 686 

Phenyl, 690 2-Methylphenyl, 691 2,6-Dimethylphenyl, 691 2-Chlorophenyl, 691 4-Chlorophenyl, 691 2,4-Dichlorophenyl, 691 

2- Trimethylsilylprop-2-enyl, 948 Hexafluoro-2-butyl, 949 Ethylene Glycol Derivative, 949 

4-[AI-Methyl-N-(2,2,2-trifluoroacetyl)amino]butyl, 952 4- (AI-Trifluoroacetylamino) butyl, 953 

2-[W-Methyl-N-(2-pyridyl)]aminoethyl, 954 2- (A-Formyl-A-methyl) aminoethyl, 954 2- (W-Isopropyl-iV-anisoylamino) ethyl, 954 2- [(l-Naphthyl)carbamoyloxy] ethyl, 954 2-[W-Isopropyl-A-(4-methoxybenzoyl)amino]ethyl, 955 

Greene s Protective Groups in Organic Synthesis, Fourth Edition, by Peter G. M. Wuts and Theodora W. Greene 

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A number of standard synthetic reference books are available. A review article by Kossell and Seliger discusses protective groups used in oligonucleotide syntheses, including protection for the phosphate group, which is not included in this book, and a series of articles describe various aspects of protective group chemistry. 

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