Protection for Phenols and Catechols

2-Formylbenzenesulfonate, 170 PROTECTION FOR CATECHOLS CYCLIC ACETALS AND KETALS 

Some of the more important phenol and catechol protective groups are included in Reactivity Chart 4.  

See also E. Haslam, Protection of Phenols and Catechols, in Protective Groups in Organic Chemistry, J. F. W. McOmie, Ed., Plenum Press, New York and London, 1973. pp. 145-182. 

Methoxymethyl. 257 Benzyloxymethyl, 258 Methoxyethoxymethyl, 258 2-(Trimethylsilyl)ethoxymethyl, 259 Methylthiomethyl, 259 Phenylthiomethyl, 259 Azidomethyl, 260 Cyanomethyl, 260 2,2-Dichloro-1,1-difluoroethyl, 260 2-Chloroethyl, 261 2-Bromoethyl, 261 Tetrahydropyranyl, 261 1-Ethoxyethyl, 261 Phenacyl, 262 

4-Bromophenacyl, 262 Cyclopropylmethyl, 262 Allyl, 262 Propargyl, 264 Isopropyl, 264 Cyclohexyl, 265 t-Butyl, 265 Benzyl, 266 

4-Methoxybenzyl, 269 oNitrobenzyl, 270 2,6-Dichlorobenzyl, 270 3,4-Dichlorobenzyl, 270 4-(Dimethylamino)carbonylbenzyl, 271 4-Methylsulfinylbenzyl, 271 9-Anthry I methyl, 271 4-Picolyl, 272 Heptafluoro-p-tolyl, 272 Tetrafluoro-4-pyridyl, 272 

Formate, 276 Acetate, 276 Levulinate, 278 Pivaloate, 278 Benzoate, 279 9-Fluorenecarboxylate, 280 Xanthenecarboxylate, 280 

4-Methylsulfinylbenzyl, 282 2,4-Dimethylpent-3-yl, 282 2,2,2-Trichloroethyl, 282 Vinyl, 282 Benzyl, 283 Aryl Carbamates, 283 

Methoxymethyl, 382 Benzyloxymethyl, 385 Methoxyethoxymethyl, 385 2- (Trimethylsilyl) ethoxy methyl, 3 86 Methylthiomethyl, 387 Phenylthiomethyl, 387 Azidomethyl, 387 Cyanomethyl, 388 2,2-Dichloro-l,l-difluoroethyl, 388 2-Chloroethyl, 388 2-Bromoethyl, 388 f-Butyldiphenylsilylethyl, 389 Tetrahydropyranyl, 389 1-Ethoxyethyl, 389 Phenacyl, 389 

Cyclohex-2-en-l-yl, 394 Propargyl, 394 Isopropyl, 394 Cyclohexyl, 395 f-Butyl, 396 Benzyl, 396 

Greene s Protective Groups in Organic Synthesis, Fourth Edition, by Peter G. M. Wuts and Theodora W. Greene 

Formate, 410 Acetate, 411 Levulinate, 413 Pivaloate, 413 Benzoate, 414 9-Fluorenecarboxylate, 416 Xanthenecarboxylate, 416 

Methylene, 424 Pivaldehyde Acetal, 426 2-BOC-ethylidene, 426 2-Moc-ethylidene, 426 Acetonide, 426 Cyclohexylidene, 427 Diphenylmethylene, 427 Ethyl Orthoformate, 428 Diisopropylsilylene Derivative, 428 

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PROTECTION FOR PHENOLS AND CATECHOLS 24. 4-Picolyl Ether ArOCH2-4-pyridyl (Chart 4) Formation /Cleavage ... 

Reactivity Chart 4. Protection for Phenols and Catechols (Continued)... 

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