Protease inhibitor receptors

This type of analysis is now well established and has been used in many drug discovery projects over the past fifteen years. Examples include HIV protease inhibitors [13], anti-influenza drugs [14], isoform-selective ligands for the estrogen receptor [15], and many more. 

Cl, C2...C9 The 9 main components of complement Cl inhibitor A serine protease inhibitor which inactivates Clr/Cls Clq Complement fragment Iq ClqR Receptor for Clw facilitates attachment of immune complexes to mononuclear leucocytes and endothelium... 

Protease inhibitors Histamine2 receptor antagonists Other Isoniazid Cocaine Opioids Verapamil... 

Diaryl-5-anilino-l,2,4-thiadiazoles are found to be potent and selective melanocortin-4-receptor (MC4) agonists for potential use for nerve regeneration and drug addiction <2003BMG185>. Compounds like 56 are being developed as cysteine protease inhibitors (see also Section 5.07.10) <2005JOC6230>. 

CCK-B. Protease inhibitors that slow the degradation and inactivation of endogenous CCK promote satiety via CCK-A receptor. By contrast, the CCK-B receptor is important in mediating anxiety and panic attacks, and CCK antagonists are in clinical use to treat these symptoms. 

Thrombin, Inflammation, and Protease-Activated Inhibitor Receptors... 

Perez, C., Pastor, M., Ortiz, A.R., and Gago, F. Comparative binding energy analysis of HIV-1 protease inhibitors incorporation of solvent effects and validation as a powerful tool in receptor-based drug design. /. Med. Chem. 1998, 41, 836-852. 

Drugs that may be affected by PDE5 inhibitors include alpha-blockers, amlodipine, angiotensin II receptor blockers, bendroflumethiazide, enalaphl, metoprolol, nifedipine, nitrates, protease inhibitors. 

Heparin has been found to bind a large number of proteins (Table 3). The biological activity of heparin and related polysaccharides is usually ascribed to their interaction with heparin-binding proteins. These proteins can be classified into classes including (1) enzymes, (2) protease inhibitors, (3) lipoproteins, (4) growth factors, (5) chemokines, (6) selectins, (7) extracellular matrix proteins, (8) receptor proteins, (9) viral coat proteins, (10) nuclear proteins, and (11) other proteins (1). Many heparin-binding proteins are enzymes and enzyme inhibitors. For example, proteases in the coagulation cascade, such as factors Ha, IXa, Xa, Xlla, and Villa, are heparin-... 

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