Prostanoids vasodilatory

Vasodilatory prostanoids tend to promote renal salt and water excretion. The natriuretic effect of PG is in part related to their positive influence on... 

Changes in the pattern of prostanoid production during obstructive uropathy affect renal function primarily through alterations in renal haemodynamics. In general, enhanced biosynthesis of vasodilatory prostanoids occurs with acute obstruction, while increases in thromboxane synthesis prevail in the later stages. The role of eicosanoids in obstruction will be discussed in detail below. 

Animal models of diseases, as well as studies in patients with congestive heart failure, liver cirrhosis or renal insufficiency, have shown that prostanoids contribute to normal renal function by regulating vascular tone and normal blood flow (Harris, 2002 Parente and Perretti, 2003). PGE is involved in the regulation of sodium reabsorption, and its inhibition results in sodium retention that can manifest clinically in a variety of ways, such as peripheral edema, increased blood pressure, weight gain, and occasionally deterioration or heart failure. PGI increases potassium secretion and, since it has vasodilatory properties, it increases renal blood flow and glomerular filtration rate (Harris, 2002). 

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