Prostaglandins susceptibility factors

As more experience accumulates it appears clear that COX-2 inhibitors have a nephrotoxic potential similar to that of the non-selective NSAIDs. Sixteen cases of tubulointerstitial nephritis were reported to the manufacturers of celecoxib between the time when it was launched in 1999 and July 2001, but the diagnosis was not confirmed in 12 of these cases (10). Most of these renal adverse reactions occur in patients with susceptibility factors associated with prostaglandin-dependent renal function (11-13). 

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