Prostaglandins clinical thrombosis

Summary - Many diverse novel compounds that inhibit different platelet functions show great promise, not only for potential anti-thrombotic agents, but also for more specific effects on prostaglandin and/or thromboxane A2 synthesis, and serotonin or calcium uptake and release. Many active compounds can be used as tools in the search toward a more complete understanding of the physiologic interactions of the hemostatic mechanisms. This better understanding would lead to the development and use of more potent and selective synthetic compounds in the inhibition of platelet aggregation and fibrin formation, and in the enhancement of fibrinolysis for the control of both arterial and venous thrombosis. It is hoped that some of these new compounds will be evaluated clinically in the near fu ture. 

Prostaglandins have, potentially, very important applications in a wide range of clinical conditions, e.g. in the treatment of hypertension and thrombosis, as well as for contraception, the induction of abortions and the relief of asthma and peptic ulcers. However, much more work needs to be done before they can be put to routine use. 

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