Prostaglandins antidepressant action

Since IL-6 stimulates Prostaglandin E2 (PGE2) and antidepressants inhibit the IL-6 production, an inhibiting action of antidepressants on PGE2 would be expected, too (Poliak and Yirmiya, 2002). Over twenty years ago it was suggested that antidepressants inhibit PGE2 (Mtabaji et al., 1977). A recent in-vitro study showed that both tricyclic antidepressants and selective serotonin inhibitors attenuated cytokine-induced PGE2 and nitric oxide production by inflammatory cells (Yaron et al., 1999). 

Mtabaji JP, Manku MS, Honobin DE (1977) Actions of the dicy-clic antidepressant clomipramine on responses to pressor agents, hiteractions with prostaglandin E2. Prostaglandins 14 125—132. 

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