Prostaglandine analog

An analogous study concerned with the synthesis of prostaglandin analogs was also highly diastereoselective. The initial anionic adducts were quenched with various aldehydes, however, the diastereoselectivity at the carbinol stereocenter was not reported21. 

Prostaglandin Analogs Latanoprost Prostaglandin Xalatan Solution 0.005 1 drop every night Increases aqueous... 

Prostaglandin analogs Latanoprost Prostaglandin F2a analog Xalatan Solution... 

NSAID with analgesic properties, and misoprostol, a Gl mucosal protective prostaglandin analog. 

Chemical structures of some prostaglandins and prostaglandin analogs currently in clinical use. 

Collins, P. W. Synthesis of Therapeutically Useful Prostaglandin and Prostaglandin Analogs, Chem. Rev. 1993, 93, 1533. 

A number of brilliant total syntheses of natural prostaglandins have been developed and these also have provided a number of interesting prostaglandin analogs (see Exercise 30-24). The biosynthesis of prostaglandins proceeds by oxygenation at Cl l of unsaturated fatty acids. This is followed by... 

Strained alkenes such as norbomene, norbomadiene and bicyclo[2.2.2]octenes readily insert into ir-allyl complexes with the less substituted allyl terminus linked to the alkene (equation 81).233-261 This reaction has been utilized to prepare interesting prostaglandin analogs.233 234... 

MNakane. Preparation and formulation of 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs useful in treatment of thrombolic disease. U.S. Patent 4,663,336, 1987. 

Cyclohexyl prostaglandin analogs derivatized with 3-chloro-benzo[b]thiophen-2-yl, (V), prepared by Old (5) were effective as EP4 agonists and used in the treatment and management of glaucoma. 

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