Prostaglandins nociceptive effect

Chizh BA, Hies P (2001) P2X receptors and nociception. Pharmacol Rev 53(4) 553-68 Choudry NB, Fuller RW, Pride NB (1989) Sensitivity of the human cough reflex effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis... 

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) and is the active ingredient in both the gel and patch formulations described in this chapter. Diclofenac inhibits the enzyme cyclooxygenase (COX), an early component of the arachidonic acid cascade, resulting in reduced formation of prostaglandins, thromboxane, and prostacyclin. It is not completely understood how reduced synthesis of these compounds results in therapeutic efficacy. The chief therapeutic effects of diclofenac are anti-inflammatory activity, anti-nociception and antipyresis. When applied topically (via gel or patch), diclofenac is absorbed into the epidermis. However, the amount of topical diclofenac absorbed and the ultimate systemic exposure is substantially less than that seen after oral administration of the compound. 

D. Brenn, F. Richter, H. Schaible, Sensitization of unmyelinated sensory fibers o the joint nerve to mechanical stimuli by interleukin-6 in the rat An inflammator mechanism of joint pain. Arthritis Rheum., 56 (1), 351-359,2007. http //dx.doi.org/10.1002/art.22282. K.J. Bar, et al. Changes in the effect of spinal prostaglandin E2 during inflammation Prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint, J. Neuroscl, 24 (3), 642-651, 2004. http //dx.doi.org/ 10.1523/JNEUROSCI.0882-03.2004. 

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