Prostaglandin endoperoxides isolation

S. Moncada, R.J. Gryglewski, S. Bunting, J.R. Vane, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263 (1976) 663. 

Moncada S, Gryglewski R, Bunting S, and Vane JR. (1976). The enzyme isolated fiom arteries transforms prostaglandin endoperoxides to an unstable substaiKe that inhibits platelet aggregatioiL Nature (Lond.) 263,663-665. 

Hamberg, M., Svensson, J., Wakabayashi, T and Samuelsson, B. (1974). Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc. Natl. Acad. Sci. USA, 71, 345-349... 

Gerritsen, M.E. and Cheli, C.D. (1983). Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells. ]. Clin. Invest., 72, 1658-1671... 

The finding that the prostaglandin endoperoxides were potent stimulators of the isolated rabbit aorta [6,11] brought to mind the so-called rabbit aorta contracting... 

MiheUch, E. Structure and stereochemistry of novel endoperoxides isolated from the sensitized photooxidation of methyl Unoleate. Implications for prostaglandin biosynthesis. / Am. Chem. Soc. 102, 7141-7143 (1980). 

Finally in this section, useful ruthenium(n)-catalysed reactions of 1,4-epi-peroxides have been observed. One example as a highlight is the smooth fragmentation of a prostaglandin endoperoxide in the presence of 3 mol % of [RuCl8(PPhs)8] to give methyl (5Z,8 ,10 , 125 )-12-hydroxyheptadeca-5,8,10-trienoate (HHT methyl ester) as the sole isolable product (Scheme 13). The... 

Merlie JP, Fagan D, Mudd J, Needleman P. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J Biol Chem 1988 263 3550-3553. 

G02A D Prostaglandins About 15 prostaglandins have been isolated from animal and humans (isolated from sperm), where they are biosynthetised from linoleic acid (from food) via arachidonic acid and a cyclic endoperoxide (from which prostacyclin and thromboxane are also formed). There are four series of prostaglandins based on the substitution pattern in the cyclopentane ring... 

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