Prostaglandin catabolism

A Hungarian research group reported on the hypotensive activity of 3-(pyrazol-l-yl)pyridazines of type (72) in rats [253-256]. The activity of these compounds (in which both of the hydrazino nitrogen atoms are incorporated into a five-membered aromatic ring system) has been found to be mediated by inhibition of prostaglandin-catabolizing enzymes. 

Pace-Asciak, C.R. (1976). Decreased renal prostaglandin catabolism precedes the onset of hypertension in the developing spontaneously hypertensive rat. Nature (London), 263, 510-512... 

Tai, H. H., C. M. Ensor et al. 2002. Prostaglandin catabolizing enzymes. Prostaslandins Other Livid Medial 68-69 483-493. 

Tai, HH, Ensor, CM, Tong, M, Zhou, H and Yan, F (2002) Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat, 69, 483-493. 

Ivanov AI, Romanovsky A A (2004) Prostaglandin E2 as a mediator of fever synthesis and catabolism. Front Biosci 9 1977-1993... 

Prostaglandins (PG s) are naturally occurring intercellular messengers. In fact, many of the actions of anabolic substances fail to exert their protein synthesis actions without them. It is a clinical fact that there is a parallel between the rise of some levels of PG s and the degradation of catabolism. So they may in part be the relay between receptor-sites and translation to specific responses, or secondary messengers. 

Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot. Essent. Fatty Acids 2002 67 79-83. 

Embryemic development, see also Pregnancy cretinism, 737 neural tube defects, 314 prostaglandin F, 646 taurine, 103 thromboxane A, 646 transcription factors, 589 vitamin A. 565,5S9 zinc and, 813-814 Encephalocele, 514 Endocrine cells, 63,163 Endocytosis, 83,335 Endonuclease, 897 Endoplasmic nettculum (ER) alcohol catabolism in, 247 choline deficiency, 317 lipid digestion, 96 membrane-bound proteins, 40 polypeptide synthrais and transportation, 39-40... 

Prostaglandin Dg follows the same basic principles outlined above, but in humans at i, least, a different pattern of catabolism may occur. It has been found that a sizeable pro-I portion of urinary metabolites obtained following injection are recovered as metabolites E of PGF compounds (46). For this to occur, the s 11-keto group of PGDg must be reduced, but it... 

Biomolecules are constructed from a small set of building blocks. The highly diverse molecules of life are synthesized from a much smaller number of precursors. The metabolic pathways that generate ATP and NADPH also provide building blocks for the biosynthesis of more complex molecules. For example, acetyl Co A, the common intermediate in the breakdown of most fuels, supplies a two-carbon unit in a wide variety of bio syntheses, such as those leading to fatty acids, prostaglandins, and cholesterol. Thus, the central metabolic pathways have anabolic as well as catabolic roles. 

Eicosanoids (like prostaglandin) exert specific physiological effects on target cells, like hormones. However, eicosanoids are distinct from most hormones in that they cat locally, near their sites of synthesis, and they are catabolized extremely rapidly. Thus, eicosanoids are considered to be locally acting hormones. 

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