Propoxyphene dosage

Many propoxyphene-related deaths have occurred in patients with histories of emotional disturbances, suicidal ideation or attempts, or misuse of tranquilizers, alcohol, and other CNS-active drugs. Deaths have occurred as a consequence of the accidental ingestion of excessive quantities of propoxyphene alone or in combination with other drugs. Do not exceed the recommended dosage. 

IV Low Yes Dextropropoxyphene dosage forms NA (Darvon, Propoxyphene, Darvocet)... 

Accelerated or stress stability studies for the purpose of predicting sample shelf life at normal conditions have been investigated for many years. In addition, some examples of stress stability studies for sample comparison have been described. Goldberg and Nightingale (25) compared the stability of aspirin in a combined dosage form with propoxyphene. The hydrolysis... 

Goldberg R, Nightingale CH. Stability of aspirin in propoxyphene compound dosage forms. Am J Hosp Pharm 1977 34 267-269. 

Psychiatric A 60-year-old woman developed a psychosis after taking dextromethorphan at more than the recommended over-the-counter dosage, propoxyphene, and hydrocodone [71 ]. She developed religious and paranoid delusions, olfactory and visual hallucinations, and agitation. Propoxyphene may have slowed the metabolism of dextromethorphan, resulting in intoxication. 

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