Propofol Opiates

In addition to the medicines mentioned above, a number of opiate- and non-opiate-based analgesics, including COX-2 inhibitors, anaesthetics (e.g. propofol, desflurane, sevoflurane, ropivacaine, levobupivacaine and remifentanil), neuromuscular blockers (e.g. rocuronium bromid, zemuron, cisatracuiium, doxacurium. 

D. Propofol has been used for treatment of opiate withdrawal. 

A. Additive effect with other CNS depressants that may result in lower propofol dosage requirements if given concomitantly. Through its inhibition of cytochrome P-450, propofol may increase levels of midazolam, diazepam, and other opiates such as sufentanyl and alfentanyl, causing respiratory depression, bradycardia, and hypotension. 

Renal disease Sugammadex is primarily cleared by the kidneys. In 15 adults with end-stage renal failure and 15 controls, anesthesia was induced and maintained using intravenous opiates and propofol [29 ]. There was no significant difference in the time from administration of sugammadex to recovery, no evidence of recurrence of neuromuscular blockade, and no sugamma-dex-related serious adverse events. 

---